Use of ursodeoxycholic acid in liver diseases
نویسندگان
چکیده
منابع مشابه
Ursodeoxycholic acid in the treatment of liver diseases.
Ursodeoxycholic acid is a dihydroxy bile acid with a rapidly expanding spectrum of usage in acute and chronic liver diseases. The various mechanisms of action of this hydrophilic bile acid include direct cytoprotection, detergent action on dysfunctional microtubules, immunomodulation and induction of hypercholeresis. Its efficacy in primary biliary cirrhosis and primary sclerosing cholangitis a...
متن کاملNew therapies Ursodeoxycholic acid in the treatment of liver diseases
Ursodeoxycholic acid is a dihydroxy bile acid with a rapidly expanding spectrum of usage in acute and chronic liver diseases. The various mechanisms of action of this hydrophilic bile acid include direct cytoprotection, detergent action on dysfunctional microtubules, immunomodulation and induction ofhypercholeresis. Its efficacy in primary biliary cirrhosis and primary sclerosing cholangitis as...
متن کاملUrsodeoxycholic acid in chronic liver disease.
The hydrophilic bile acid ursodeoxycholic acid has recently been shown to reduce biochemical markers of both cholestasis and hepatocellular damage in patients with chronic liver diseases. The most compelling evidence available is for chronic cholestatic liver diseases, in particular primary biliary cirrhosis, primary sclerosing cholangitis, and cholestasis associated with cystic fibrosis. The e...
متن کاملUrsodeoxycholic Acid in Treatment of Non-cholestatic Liver Diseases: A Systematic Review
Aims: To systematically evaluate the literature for evidence to support the use of bile acids in non-cholestatic liver conditions. Methods: Searches were conducted on the databases of Medline (1948-March 31, 2015), Embase (1980-March 31, 2015) and the Cochrane Central Register of Controlled Trials, and on Google and Google Scholar to identify articles describing ursodeoxycholic acid (UDCA) and ...
متن کاملThe Therapeutic Role of Ursodeoxycholic Acid in Digestive Diseases
Ursodeoxycholic acid (UDCA) makes up a small portion of the naturally occurring bile acid pool in humans, and the drug is effective in several diseases. The mechanism of action involves the displacement of more toxic endogenous bile acids, direct protection of hepatocytes against apoptosis, and stimulation of endogenous secretion of bile to alleviate cholestasis. The use of UDCA has been studie...
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ژورنال
عنوان ژورنال: Journal of Gastroenterology and Hepatology
سال: 2001
ISSN: 0815-9319,1440-1746
DOI: 10.1046/j.1440-1746.2001.02376.x